Blar i forfatter "Thomassen, Ernst Ivan"

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    • Pax6 Represses Androgen Receptor-Mediated Transactivation by Inhibiting Recruitment of the Coactivator SPBP 

      Elvenes, Julianne; Thomassen, Ernst Ivan; Johnsen, Sylvia Sagen; Kaino, Katrine; Sjøttem, Eva; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The androgen receptor (AR) has a central role in development and maintenance of the male reproductive system and in the etiology of prostate cancer. The transcription factor Pax6 has recently been reported to act as a repressor of AR and to be hypermethylated in prostate cancer cells. SPBP is a transcriptional regulator that previously has been shown to enhance the activity of Pax6. In this study ...

    • Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts 

      Sobhkhez, Mehrdad; Skjesol, Astrid; Thomassen, Ernst Ivan; Iliev, Dimitar Borisov; Sun, Baojian; Robertsen, Børre; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, however, description of their functional activity in lower vertebrates is still scarce. In the present study we ...